I-CYANOCOBALAMIN (IVITAMINI B12)
Isimo kanye nezakhiwo
Lo mkhiqizo uyi-crimson crystal noma i-crystalline powder, awunaphunga, awunambitheki futhi unezakhiwo ezinamandla ezibangela umswakama. Uncibilika kancane emanzini noma e-ethanol, awuncibiliki ku-chloroform noma ku-ether. Umelana nokushisa, kodwa ungangasebenzi uma ubhekene nezinto ezikhipha i-oxidizing noma ezinciphisayo, usawoti wensimbi esindayo nama-acid aqinile kanye nama-alkali aqinile.
Isakhiwo Samakhemikhali
I-Vitamin B12 iyinhlanganisela ye-equioctaphedral equkethe ama-ion e-cobalt. Isakhiwo sayo esiphakathi siyindandatho ye-corrin eyisicaba eyakhiwe ngama-pyrroles amane axhunyiwe. Ama-molecule e-vitamin B12 akhiwe cishe izingxenye ezintathu: indandatho ye-gourin e-chylated ngama-athomu amane e-N nama-ion e-cobalt aphakathi; ama-5,6-dimethylbenzimidazole axhunywe kuma-athomu e-N-7 nama-ion e-cobalt njengama-molecule e-vitamin B 12 ama-ligands aphansi. Ngaphezu kwalokho, i-DMBI ixhunywe futhi kuma-aminopropanol ngamaqembu e-phosphate, kanti i-aminopropanol ixhunywe ndawonye neketanga eliseceleni le-propionic acid ku-pyrrole D; iqembu le-adenosyl noma iqembu le-methyl. Ixhunywe kuma-ion e-cobalt ukwakha i-ligand ephezulu yama-molecule e-vitamin B12.
Umsebenzi Wezinto Eziphilayo
Ukuntuleka kwe-Vitamin B12 kungaholela ku-peripheral neuritis. Ukubonakaliswa kokuqala kokuntuleka kwe-vitamin B12 ezinganeni yimizwa engavamile, ukusabela okuvilaphayo, ukusabela kancane, futhi ekugcineni kuholele ekulahlekelweni kwegazi. Kukhuthaza ukuthuthukiswa nokuvuthwa kwamaseli abomvu egazi. I-Methylpropandiyl coenzyme A iguqulwa ibe yi-succinoyl coenzyme A futhi ihlanganyela emjikelezweni we-tricarboxylic acid, lapho i-succinyl coenzyme A ihlobene nokuhlanganiswa kwe-heme. I-Vitamin B12 ihlanganyela futhi ekwakhiweni kwe-deoxynucleic acid (DNA), i-metabolism yamafutha, ama-carbohydrate namaprotheni, futhi ikhulisa ukuhlanganiswa kwama-nucleic acid namaprotheni.
